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Alignments this size can be analyzed because of the extensive optimizations made to the covariation calculation software. Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians.
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Kanehisa M, Goto S, Kawashima S, Nakaya A (2002) The kegg databases at genomenet.

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Figure 5 Role of autophagy during L. monocytogenes intrachamberular escape and growth.

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